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Unlike other oral treatments for erectile dysfunction, UPRIMA stimulates dopamine receptors in the brain.
These receptors in turn transmit excitatory signals down the spinal cord to the sacral parasympathetic nucleus, stimulating activity of the sacral nerves supplying the penis.
As the penile smooth muscle relaxes, the pelvic arteries dilate. The dilated arteries then fill with blood and the penis becomes erect.
This is the most commonly asked question! One of the main benefits of UPRIMA is the speed at which it works.
Once dissolved under the tongue, clinical test have shown that 34% of erections occurred within 10 minutes and 71% of erections occurred within 20 minutes. That puts the average time to the onset of an erection at 18-19 minutes - 200% faster than Viagra !
UPRIMA is the first clinically tested and medically approved oral treatment for erectile dysfunction, which works in the brain making UPRIMA totally different from any other treatment
The most common side-effects recorded of those using UPRIMA are as follows:

Headache - 7%
Nausea - 7%
Dizziness - 4%

Nausea is generally mild to moderate in nature declining with continued use.

It is recommended that patients start with a 2mg dose and increase to 3mg if necessary to reach the desired clinical effect.

In other words, first start with the 2mg dose and when you next re-order - go for the 3mg if necessary. Most of you will find that 2mg is ample and will not need to increase the dosage.



Those suffering from severe unstable angina, recent myocardial infarction, severe heart failure or any other condition where sexual activity is inadvisable.
UPRIMA should be used with caution in patients taking anti-hypertensives or nitrate medications.

Your health and well being is our primary concern and we would therefore strongly suggest that if you are in any doubt whatsoever in the use of UPRIMA, you must contact your own doctor for further advice. Before taking UPRIMA, read thoroughly the manufacturers advise enclosed with this treatment. Again, if you are unclear as to your suitability for this treatment, consult your doctor before use.

It is recommended that you take the UPRIMA sublingual tablet 20 minutes prior to sexual activity. It is best to drink a small glass of water before taking the tablet to help the dissolving process.

After drinking the water, place the tablet under the tongue. Do not chew , just let the tablet dissolve.

In the majority of patients, the tablet will be dissolved within 10 minutes. An erection should occur when sexual activity starts.

Shipping and handling prices (total price, there are no hidden fees):

USA, Territories and APOs: Priority (Registered Air Mail) (12-15 days*) $12    Express (EMS) (5-8 days*) $22

Canada: Priority (Registered Air Mail (12-15 days*) $20    Express (EMS) (5-8 days*) $35

EU and other countries (listed on order form): Priority (Registered Air Mail) $15   Express (EMS) $35

* Business days (M-F, excluding holidays)